ea0011p631 | Neuroendocrinology and behaviour | ECE2006
Rousseau K
, Kauser S
, Prtichard LE
, Warhurst A
, Oliver RL
, Schmitz CA
, Thody AJ
, Tobin DJ
, White A
Pro-opiomelanocortin (POMC) is endoproteolysed to ACTH and alpha MSH which bind to the melanocortin-1 receptor, (MC-1R), and act as principal mediators of human skin pigmentation. In addition there is increasing evidence that alpha MSH has important anti-inflammatory actions in the skin. The aim of this study was to determine the efficiency of processing and the involvement of the different peptides in melanogenesis. To address this question we utilized specific two-site immun...